Hiroji Iwata Selected Research

Biomarkers (Surrogate Marker)

1/2023	Efficacy and exploratory biomarker analysis of entinostat plus exemestane in advanced or recurrent breast cancer: phase II randomized controlled trial.
1/2023	Efficacy, safety, and biomarker analysis of nivolumab in combination with abemaciclib plus endocrine therapy in patients with HR-positive HER2-negative metastatic breast cancer: a phase II study (WJOG11418B NEWFLAME trial).
1/2023	Association Between Biomarkers and Clinical Outcomes of Pembrolizumab Monotherapy in Patients With Metastatic Triple-Negative Breast Cancer: KEYNOTE-086 Exploratory Analysis.
3/2021	Current status of PD-1/PD-L1 blockade immunotherapy in breast cancer.
1/2021	Atezolizumab and nab-Paclitaxel in Advanced Triple-Negative Breast Cancer: Biomarker Evaluation of the IMpassion130 Study.
11/2019	PIK3CA alterations and benefit with neratinib: analysis from the randomized, double-blind, placebo-controlled, phase III ExteNET trial.
1/2017	Buparlisib plus fulvestrant versus placebo plus fulvestrant in postmenopausal, hormone receptor-positive, HER2-negative, advanced breast cancer (BELLE-2): a randomised, double-blind, placebo-controlled, phase 3 trial.
3/2015	Efficacy, safety, pharmacokinetics and biomarker findings in patients with HER2-positive advanced or metastatic breast cancer treated with lapatinib in combination with capecitabine: results from 51 Japanese patients treated in a clinical study.
8/2013	A multicenter phase II study of TSU-68, a novel oral multiple tyrosine kinase inhibitor, in patients with metastatic breast cancer progressing despite prior treatment with an anthracycline-containing regimen and taxane.
10/2010	Cytoplasmic expression of the JM403 antigen GlcA-GlcNH3+ on heparan sulfate glycosaminoglycan in mammary carcinomas--a novel proliferative biomarker for breast cancers with high malignancy.

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Hiroji Iwata Research Topics

Disease

258	Breast Neoplasms (Breast Cancer) 04/2024 - 01/2002
96	Neoplasms (Cancer) 04/2024 - 01/2002
28	Neoplasm Metastasis (Metastasis) 12/2023 - 10/2002
24	Neutropenia 11/2023 - 08/2008
19	Triple Negative Breast Neoplasms 12/2023 - 12/2012
18	Disease Progression 04/2024 - 01/2007
7	Diarrhea 06/2023 - 12/2015
6	Carcinoma (Carcinomatosis) 01/2024 - 10/2002
6	Fatigue 10/2022 - 07/2015
6	Leukopenia 09/2021 - 08/2008
5	Vomiting 01/2021 - 10/2007
5	Nausea 01/2021 - 10/2007
5	Febrile Neutropenia 01/2020 - 10/2007
5	Brain Neoplasms (Brain Tumor) 11/2017 - 08/2013
4	Pathologic Complete Response 11/2023 - 04/2011
4	Interstitial Lung Diseases (Interstitial Lung Disease) 01/2023 - 08/2020
4	Pneumonia (Pneumonitis) 01/2023 - 08/2020
4	Thrombocytopenia (Thrombopenia) 08/2022 - 01/2015
4	Anemia 01/2021 - 11/2014
4	Stomach Neoplasms (Stomach Cancer) 01/2020 - 04/2002
4	Stomatitis 12/2019 - 11/2014
4	Carcinogenesis 10/2019 - 02/2003
4	Hand-Foot Syndrome 11/2018 - 10/2010
4	Ductal Carcinoma 09/2018 - 06/2006
4	Edema (Dropsy) 03/2017 - 01/2005
3	Arthralgia (Joint Pain) 10/2023 - 01/2005
3	Peripheral Nervous System Diseases (PNS Diseases) 01/2022 - 01/2020
3	Lymphatic Metastasis 10/2021 - 11/2002
3	Noninfiltrating Intraductal Carcinoma (DCIS) 03/2021 - 08/2017
3	Alopecia (Baldness) 11/2020 - 12/2015
3	Exanthema (Rash) 01/2019 - 01/2015
3	Hyperglycemia 01/2019 - 11/2014

Drug/Important Bio-Agent (IBA)

65	Hormones (Hormone)IBA 04/2024 - 01/2002
42	Estrogen ReceptorsIBA 12/2023 - 10/2002
42	Trastuzumab (Herceptin)FDA Link 06/2023 - 10/2005
34	ErbB Receptors (EGF Receptor)IBA 01/2024 - 05/2011
24	human ERBB2 proteinIBA 12/2023 - 10/2008
22	palbociclibIBA 11/2023 - 07/2015
17	Aromatase InhibitorsIBA 03/2023 - 06/2010
17	Fulvestrant (Faslodex)FDA Link 01/2023 - 12/2013
16	Paclitaxel (Taxol)FDA LinkGeneric 01/2022 - 01/2009
14	Docetaxel (Taxotere)FDA Link 08/2021 - 01/2005
14	Cyclophosphamide (Cytoxan)FDA LinkGeneric 10/2020 - 02/2004
11	Cyclin-Dependent Kinase 4IBA 10/2023 - 01/2017
11	Biomarkers (Surrogate Marker)IBA 01/2023 - 07/2007
11	exemestane (Aromasin)FDA Link 01/2023 - 04/2011
10	abemaciclibIBA 04/2024 - 01/2019
10	trastuzumab deruxtecanIBA 01/2024 - 01/2019
10	taxaneIBA 01/2023 - 11/2009
10	Capecitabine (Xeloda)FDA Link 11/2018 - 02/2004
10	Tamoxifen FDA LinkGeneric 12/2014 - 07/2003
9	Ado-Trastuzumab EmtansineIBA 01/2023 - 01/2015
9	Letrozole (Femara)FDA LinkGeneric 01/2023 - 04/2011
9	Progesterone Receptors (Progesterone Receptor)IBA 10/2021 - 07/2003
9	AnthracyclinesIBA 10/2020 - 11/2009
8	130-nm albumin-bound paclitaxelIBA 11/2021 - 05/2017
8	atezolizumabIBA 11/2021 - 11/2018
8	Phenobarbital (Luminal)FDA Link 09/2021 - 04/2011
8	Anastrozole (Arimidex)FDA LinkGeneric 11/2014 - 06/2010
7	Proteins (Proteins, Gene)FDA Link 03/2023 - 02/2007
7	Lapatinib (GW572016)FDA Link 08/2021 - 08/2013
7	Fluorouracil (Carac)FDA LinkGeneric 04/2020 - 01/2005
7	Epirubicin (Ellence)FDA LinkGeneric 04/2020 - 02/2004
6	pembrolizumabIBA 12/2023 - 12/2020
6	neratinibIBA 01/2023 - 03/2016
6	Tyrosine Kinase InhibitorsIBA 01/2023 - 08/2013
6	pertuzumabIBA 09/2022 - 05/2018
5	LigandsIBA 05/2024 - 10/2020
5	Epidermal Growth Factor (EGF)IBA 04/2024 - 05/2010
5	EnzymesIBA 01/2023 - 04/2002
5	Bevacizumab (Avastin)FDA Link 06/2022 - 10/2011
5	B7-H1 AntigenIBA 01/2022 - 11/2018
5	Gemcitabine FDA Link 01/2022 - 11/2009
5	eribulin FDA Link 01/2018 - 06/2013
4	Immunoconjugates (Immunoconjugate)IBA 10/2023 - 01/2015
4	Immune Checkpoint InhibitorsIBA 01/2023 - 11/2017
4	Albumin-Bound Paclitaxel FDA Link 01/2022 - 04/2015
4	Carboplatin (JM8)FDA LinkGeneric 01/2022 - 06/2014
4	Monoclonal AntibodiesIBA 01/2020 - 10/2005
4	Everolimus FDA Link 10/2019 - 05/2013
4	ORALIT (ORS)IBA 02/2011 - 04/2002
3	Messenger RNA (mRNA)IBA 01/2023 - 06/2006
3	Alanine Transaminase (SGPT)IBA 01/2023 - 01/2017
3	TeaIBA 01/2022 - 08/2021
3	Estrogens (Estrogen)FDA Link 10/2019 - 04/2016
3	Doxorubicin (Adriamycin)FDA LinkGeneric 01/2018 - 09/2014
3	Goserelin (Zoladex)FDA Link 01/2017 - 04/2012
3	thiamine triphosphorate (TTP)IBA 03/2015 - 02/2010

Therapy/Procedure

119	Therapeutics 04/2024 - 07/2003
60	Drug Therapy (Chemotherapy) 03/2024 - 01/2005
23	Neoadjuvant Therapy 11/2023 - 01/2005
18	Adjuvant Chemotherapy 06/2023 - 10/2005
15	Radiotherapy 04/2024 - 09/2007
8	Segmental Mastectomy (Lumpectomy) 04/2023 - 01/2005
7	Lymph Node Excision (Lymph Node Dissection) 07/2020 - 11/2002
6	Mastectomy (Mammectomy) 12/2023 - 09/2018
5	Mammaplasty (Breast Reconstruction) 10/2023 - 09/2018
4	Drug Tapering 08/2022 - 10/2016
3	Operative Surgical Procedures 05/2019 - 05/2017
3	Duration of Therapy 01/2019 - 01/2007